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A number of
collagen matrix wound dressing have been
developed in treatment of wounds and burns
because of the importance of the extracellular
matrix in wound healing.
The addition of dermal like properties
should improve the healing process, especially
in the full thickness wound which has no
remaining dermis to orchestrate healing.
In addition, less scar should be
present if the wound heals faster.
These products also maintain a moisture
layer on the wound surface providing for moist
wound healing.
Most of the
matrix wound dressings provide a simple
artificial collagen scaffold to help organize
new tissue formation.
New cells can migrate on the collagen
fibers into the healing wound.
The structural component of the wound
matrix is however usually not in its natural
form in most products. The collagen used in most products is
also denatured so some of the active
biological properties are missing. The
addition of a glycosaminoglycan component
provides absorptive properties as well as
providing a conduit for nutrients to the new
wound tissue.
The ability of the product to improve healing
will depend on it’s structural and
functional components.
A unique wound
matrix product has been developed from porcine
small intestinal submucosa (OASIS Wound Matrix
- Healthpoint).
This tough matrix dressing contains
biologically active collagen type I in its
natural structural and functional form.
In addition, the matrix contains
biologically active glycoproteins, fibronectin
and growth factors including fibroblast growth
factors.
Application onto a wound bed should
provide a more natural matrix-like layer which
incorporates into the wound bed.
In
summary, providing a extracellular matrix-like
layer to a wound bed, should improve healing
and help control scarring. |
